Quantitative assessment of the carcinogenic risks associated with dietary exposure to acrylamide and furan, contaminates found in certain foods cooked at high temperatures. These studies are supported by an interagency agreement between National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP) and FDA to support studies of mutual benefit to FDA and NIEHS/National Institute of Health (NIH). Acrylamide and furan are heat-induced food contaminants that may be carcinogenic to humans. These substances are being assessed to determine the effects of exposure to humans. These studies will lead to a better understanding of mechanisms that contribute to a contaminant’s toxicity and the relationship to levels of exposure. These assessments will determine the carcinogenic risks of acrylamide and furan which will be used to prepare risk assessments for exposure to these chemicals at levels encountered in human food. ON TRACK ON TRACK main a. Prepare draft NCTR report on acrylamide bioassays 5/31/2010 <i>(7/30/2010)</i> Completed 7/30/2010 main b. Compile initial results on carcogenic mutations in tumor tissues from acrylamide bioassays 6/30/2010 <i>(1/1/2011)</i> <i>(12/30/2011)</i> <i>(TBD)</i> On Track main c. Submit final pathology report on glycidamide to principal investigator 12/31/2010 Completed 6/7/2011 main d. Present technical report on acrylamide bioassay to NTP Technical Report Review Committee 1/1/2011 <i>(4/30/2011)</i> Completed 4/5/2011 main e. Prepare draft NCTR report on glycidamide bioassay 4/1/2011 <i>(12/30/2011)</i> <i>(TBD)</i> Completed 7/31/2012 main f. Present technical report on glycidamide bioassay to NTP Technical Report Review Committee FY13 Q3 Not Yet Started ON TRACK ON TRACK main a. Complete an interim 36-week analysis of rodents as part of a 2-year biological assay to determine the toxic effects of the food contaminant furan (Scheduled 5/2010 - 9/2010) 9/1/2010 Completed 9/1/2010 main b. Complete an interim 60-week analysis of rodents as part of a 2-year biological assay to determine the toxic effects of the food contaminant furan (Scheduled 11/2010 - 3/2011) 3/1/2011 Completed 3/7/2011 main c. Complete an interim 60-week analysis of rodents as part of a 2-year biological assay to determine the toxic effects of the food contaminant furan (Scheduled 9/2011 - 1/2012) 1/1/2012 Completed 1/1/2012 main d. Draft pathology report & in-life statistic report 7/1/2012 <i>(FY13 Q1)</i> On Track main e. Complete pathology working group review 2/1/2013 <i>(FY13 Q2)</i> Not Yet Started main f. Finalize pathology statistics report 5/1/2013 <i>(FY13 Q3)</i> Not Yet Started main g. Prepare draft NCTR final report on furan bioassay 12/1/2013 <i>(FY14 Q1)</i> Not Yet Started main h. Present technical report on furan bioassay to NTP Technical Report Review Board TBD Not Yet Started http://www.fda.gov/AboutFDA/Transparency/track/ucm203296.htm FDA-TRACK NCTR Dashboard http://www.fda.gov/AboutFDA/Transparency/track/ucm252974.htm FDA-TRACK Research Glossary ਍††਍਍਍਍਍਍਍