Develop and improve strategies for assessing cancer mode actions for quantitative cancer risk assessments.It is important for FDA to be able to assess the level of risk for humans exposed to chemicals including food contaminants that are carcinogens. This is done using mathematical models where these models are selected based on the mode by which the chemical causes cancer.Understanding the potential hazards of dietary supplements and food contaminants as they relate to cancer will provide FDA better information for decision-making in cancer prevention.This research will improve the cancer risk assessments of dietary supplements and food contaminants.ON TRACKON TRACKmain1. Present and discuss risk assessments and biological dose-response models (to date) with the scientific community at the Society for Toxiciology Meeting3/31/2010Completed3/31/2010main2. Approve concept paper for new research program to use in vivo mutation data to inform cancer mode of action5/31/2010Completed5/1/2010main3. Approve the CRADA with FDA and TERA for collaborative research on new strategy for assessing cancer mode of action6/30/2010<i>(12/31/2010)</i>Completed2/1/2011main4. Complete discussions with external collaborators on the technical aspects and logistics for cancer mode of action research for the model chemical ethlene oxide8/31/2010Completed8/31/2010main5. Initiate the inhalation exposure for the ethylene oxide study (by external collaborators)9/30/2010<i>(3/1/2011)</i>Completed3/1/2011main6. Receive samples from external collaborator3/1/2011<i>(5/1/2011)</i>Completed5/1/2011main7. Complete the assessment of research findings1/1/2012Completed5/30/2012main8. Develop draft technical report/manuscript/publication6/1/2012On Trackmain9. Complete the peer review (NCTR and other researchers) of draft technical report, manuscript, and/or publication12/21/2012On Trackmain10. Obtain NCTR Center Director approval on the draft technical report, manuscript, and/or publication via the document tracking system2/28/2012On Trackmain11. Submit final technical report, manuscript and/or publication to a scientific journal3/31/2012On Trackconcept papera description of a planned research activity that is submitted to the NCTR Director in advance of the submission of a protocolin vivowithin a living organismCRADACooperative Research and Development AgreementTERAToxicology Excellence for Risk Assessmentchemical ethlene oxideused for medical sterilizationhttp://www.fda.gov/AboutFDA/Transparency/track/ucm203296.htmFDA-TRACK NCTR Dashboardhttp://www.fda.gov/AboutFDA/Transparency/track/ucm252974.htmFDA-TRACK Research Glossary਍††਍਍਍਍਍਍਍