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<key-projects><projects><title>Development of Bioinformatics Approaches to Characterize Foodborne Pathogens</title><description>Enhance ArrayTrack capabilities and integrate microbial omics data into the system for analysis of foodborne pathogens.</description><dictionary>ArrayTrack is software invented by NCTR scientists that allow for the management, analysis, and interpretation of vast amounts of omics data and acts as a central database for foodborne pathogens that is available to the public.</dictionary><dictionary>The expanded use of ArrayTrack and other bioinformatic tools allows the FDA to support the rapid translation of scientific research into reliable and safer treatments by improving the management of available data.</dictionary><outcome>These studies will integrate genetic information into a publicly available central database for foodborne pathogens, which will facilitate more rapid advances in food safety.</outcome><accomplishment>The FDA-TRACK project Development of Bioinformatics Approaches to Characterize Foodborne Pathogens focus on a multi-divisional effort (Divisions of Microbiology, Systems Biology and Personalized Nutrition and Medicine) to expand the capabilities of the existing molecular biological analysis program ArrayTrackTM developed at NCTR to enable the analyses of genomics and gene expression data from bacterial pathogens.  The enhanced capabilities were successfully integrated into the ArrayTrackTM program and are available for FDA and public use.  A manuscript describing the enhanced microbial analysis tools was published in the journal &lt;a href=http://www.biomedcentral.com/1471-2105/11/S6/S4 target=”_blank”&gt;BMC Bioinformatics&lt;/a&gt; and a project utilizing the new tools for the analysis of microarray data was recently published in the &lt;a href= http://www.jidc.org/index.php/journal/article/view/21389588 target=”_blank”&gt; Journal of Infection in Developing Countries&lt;/a&gt;.  By incorporating these new capabilities in a publicly available program, scientists will be able to efficiently analyze molecular data collected on foodborne pathogens, which should facilitate more rapid advances in food safety.</accomplishment><table><title></title><row><type>main</type><milestone-description>1. Integrate existing microarray data from Salmonella studies into ArrayTrack for initial analysis</milestone-description><milestone-date>4/30/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>4/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>2. Develop study objectives to generate additional microarray data to incorporate into ArrayTrack</milestone-description><milestone-date>5/31/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>5/31/2010</milestone-completion-date></row><row><type>main</type><milestone-description>3. Prepare research plan to acquire microarray slides from the Pathogen Functional Genomics Research Core</milestone-description><milestone-date>6/30/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>6/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>4. Submit revised manuscript on ArrayTrack's new functions</milestone-description><milestone-date>7/31/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>6/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>5. Complete Salmonella enterica serovar Javiana microarray analysis</milestone-description><milestone-date>8/31/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>7/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>6. Acquire additional training on the USDA antimicrobial resistance microarray platform</milestone-description><milestone-date>9/30/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>8/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>7. Complete the peer review (NCTR and other FDA researchers) of draft technical report, manuscript, and/or publication</milestone-description><milestone-date>12/31/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>11/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>8. Obtain NCTR Center Director approval on the draft technical report, manuscript, and/or publication via the document tracking system</milestone-description><milestone-date>12/31/2010</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>11/30/2010</milestone-completion-date></row><row><type>main</type><milestone-description>9. Submit the final technical report, manuscript, and/or publication to a scientific journal</milestone-description><milestone-date>3/31/2011</milestone-date><milestone-status>Completed</milestone-status><milestone-completion-date>11/30/2010</milestone-completion-date></row><footnotes><note></note></footnotes></table></projects><glossary><word><text>USDA</text><definition>U.S. Department of Agriculture</definition></word></glossary><related-links><link><url>http://www.fda.gov/AboutFDA/Transparency/track/ucm203296.htm</url><text>FDA-TRACK NCTR Dashboard</text></link><link><url>http://www.fda.gov/AboutFDA/Transparency/track/ucm252974.htm</url><text>FDA-TRACK Research Glossary</text></link></related-links></key-projects>਍††਍਍਍਍਍਍਍