Exploring mechanisms of free radical damage and toxicity to mitochondria as they relate to neurotoxicity/neurodegeneration. This study is supported by an interagency agreement between NIEHS/NTP and FDA to support studies of mutual benefit to FDA and NIEHS/ NIH. Oxidative stress is caused by an imbalance in cells between reactive oxygen and their ability to detoxify reactive oxygen. This ability is related to aging and to several diseases. Mitochondrial toxicity occurs when the mitochondria of the body's cells become damaged or decline significantly in number. These conditions are studied here in relationship to neurotoxicity and neurodegeneration, both of which can cause loss of cognitive function. These studies will provide insight into potential strategies for preventing or ameliorating the progression of neurodegenerative diseases. These studies will provide insight into potential strategies for preventing or alleviating the progression of neurodegenerative diseases which cause the progressive loss of structure or function of neurons. ON TRACK ON TRACK a. Submit protocol to assess neurotoxicity associated with cell phone radiation 10/31/2009 Completed 12/31/2009 b. Start recruiting ORISE postdoc for cell phone radiation study 1/31/2010 Completed 1/20/2010 c. Onboard ORISE postdoc and begin work on cell phone radiation study 4/30/2010 Completed 3/15/2010 d. Present results at TSSRC 5/31/2010 Completed 5/18/2010 main e. Generate data from cell phone radiation protocol in preparation for Toxicology Study Selection Review Meeting 9/30/2010 <i>(12/31/2010)</i> Completed 11/17/2010 main f. Complete assessment of research findings 5/30/2011 Completed 5/30/2011 main g. Develop draft technical report/manuscript/publication on the effects on neurotoxicity association with cell phone radiation 6/30/2011 Completed 6/30/2011 main h. Complete the peer review (NCTR and other FDA researchers) of draft technical report, manuscript, and/or publication 8/31/2011 <i>(TBD)</i> Completed 12/31/2012 main i. Obtain NCTR Center Director approval on the draft technical report, manuscript, and/or publication via the document tracking system 9/30/2011 <i>(3/15/2012)</i> <i>(FY13 Q1)</i> On Track main j. Submit final technical report, manuscript, and/or publication on neurotoxicity association with cell phone radiation to a scientific journal/NTP 11/1/2011 <i>(4/15/2012)</i> <i>(FY13 Q1)</i> On Track <b>Accomplishment:</b>Major findings from this research identified possible neuroprotective roles for carnitine compounds for 3-NPA-induced hypothermia and neuronal degeneration and resveratrol for 3-NPA evoked peripheral neuropathy. main a. Submit concept paper on oxidative stress, neurodegeneration and imaging biomarkers 11/30/2009 Completed 3/3/2010 main b. Submit concept paper on oxidative stress, nanoparticles and MRI 2/28/2010 Completed 3/15/2010 main c. Submit manuscript on oxidative stress, nanoparticles, and MRI 6/30/2010 Completed 6/15/2010 main d. Submit additional manuscript on oxidative stress, nanoparticles, and blood brain barrier to a scientific journal 7/31/2010 Completed 8/25/2010 ON TRACK ON TRACK main a. Receive and install microscope for cell culture lab 12/31/2009 Completed 12/14/2009 main b. Begin use of the confocal microscope in support of silver nanoparticles study 3/31/2010 Completed 3/8/2010 main c. Review results obtained using the confocal microscope in support of silver nanoparticles study 6/30/2010 <i>(8/30/2010)</i> <i>(12/1/2010)</i> <i>(2/28/2011)</i> Completed 2/28/2011 main d. Complete assessment research findings 12/31/2010 <i>(2/28/2011)</i> Completed 2/28/2011 main e. Submit abstract on findings to Scientific meeting 12/31/2010 <i>(2/28/2011)</i> Completed 3/23/2011 main f. Develop draft technical report/manuscript/publication on the silver nanoparticles study results 2/1/2011 Completed 3/1/2011 main g. Complete the peer review (NCTR and other FDA researchers) of draft technical report, manuscript, and/or publication 4/1/2011 Completed 4/1/2011 main h. Obtain NCTR Center Director approval on the draft technical report, manuscript, and/or publication via the document tracking system 5/1/2011 Completed 5/1/2011 main i. Submit final technical report, manuscript, and/or publication on the silver nanoparticles study results to a scientific journal/NTP 7/1/2011 Completed 8/15/2011 main j. Submit additional manuscript on the research results of this Silver Nanoparticles Study to a scientific journal. 3/1/2012 <i>(FY13 Q2)</i> On Track mitochondria cellular energy sources NIEHS National Institute of Environmental Health Sciences NTP National Toxicology Program NIH National Institutes for Health carnitine compounds present in muscle and liver and involved in the transport of fatty acids across mitochondrial membranes neuronal degeneration progressive loss of structure or function of neurons resveratrol a natural compound found in grapes, mulberries, peanuts, and other plants or food products, especially red wine, that may protect against cancer and cardiovascular disease by acting as an antioxidant, antimutagen, and anti-inflammatory neuropathy nerve damage ORISE Oak Ridge Institute for Science and Education TSSRC Toxicology Study Selection Review Committee concept paper description of a planned research activity that is submitted to the NCTR Director in advance of submission of a protocol biomarkers measurable characteristics that indicate the transition between biological states such as healthy or diseased MRI Magnetic Resonance Imaging http://www.fda.gov/AboutFDA/Transparency/track/ucm203296.htm FDA-TRACK NCTR Dashboard http://www.fda.gov/AboutFDA/Transparency/track/ucm252974.htm FDA-TRACK Research Glossary ਍††਍਍਍਍਍਍਍