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U.S. Department of Health and Human Services

About FDA

NARMS Measures

Description: Develop better molecular techniques for the characterization of isolates. This project will provide more rapid identification and characterization of foodborne pathogens. It will provide information to better understand and combat antimicrobial resistance in foodborne pathogens.

Definition: This program monitors antibiotic resistance trends in foodborne bacteria recovered from humans, farm animals and retail meats in order to identify emerging patterns that may require interventions. This ongoing data collection also helps FDA to formulate regulatory policies to limit the development and spread of resistant bacteria in the food supply.

Milestone DescriptionMilestone DateMilestone StatusMilestone Completion Date

1. Develop rapid testing methods for strain analysis (analysis of a segment of DNA/biological material):

7/30/2011

(3/30/2012)

Completed 3/30/2012

a. Troubleshoot and enhance low-density array for detection of antibiotic resistance gene in foodborne bacteria

12/15/2010

Completed 12/15/2010

b. Design high-density microarray platform to analyze foodborne bacteria

7/30/2011

(3/30/2012)

Completed 3/30/2012

c. Submit manuscript to a journal for publication

3/30/2012

(8/31/2012)

(3/30/2013)

(7/31/2013)

(2/28/2014)

Completed 3/3/2014

2. Expand the number of NARMS isolates with sequence information on resistance genes:

7/30/2011

(3/30/2012)

Completed 3/30/2012

a. Sequence resistance plasmids (circular segments of DNA that are external to chromosomal DNA and are easily transferable between cells) from Salmonella Typhimurium (a type of salmonella that has been especially problematic in recent human infections)

3/30/2011

(3/30/2012)

Completed 3/30/2012

b. Compare gene sequences in susceptible and resistant Salmonella (Heidelberg) Newport (a type of salmonella that causes significant clinical disease in humans and livestock)

6/30/2011

(9/30/2011)

(3/30/2012)

Completed 3/30/2012

c. Draft manuscript or final report based on findings

12/30/2012

(3/31/2013)

(8/31/2013)

(12/13/2013)

Completed 3/3/2014

Footnotes

  • (1) The dates in italics under the milestone due dates are modified due dates which had to be updated due to real-time delays. The milestone status reflects the modified dates.

Key Projects Legend

Milestone StatusDefinition
Not Yet StartedWork for specific milestone has not yet been started.
CompletedMilestone and/or overall project is completed.
On TrackMilestone - On track for completion by milestone deadline. Quarter status - Project is on track for completion based on overall milestone status.
On HoldMilestone - On hold, but deadline for completion has not passed. Quarter status - Project is on hold, based on overall milestone status.
DelayedMilestone - Delayed as it has not been completed and deadline has passed. Quarter status - Project is delayed based on overall milestone status.

Glossary

isolates

DNA or proteins that have been separated in pure form from a combined mixture

pathogens

microbes that cause a diseased state in a host (i.e. virus, bacteria, parasites)

strain analysis

analysis of a segment of DNA/biological material

NARMS

National Antimicrobial Resistance Monitoring System (NARMS)

resistance plasmids

circular segments of DNA that are external to chromosomal DNA and are easily transferable between cells

Salmonella Typhimurium

a type of salmonella that has been especially problematic in recent human infections

Note: The data provided on this website is produced on an ongoing basis for performance management purposes and is subject to change due to updates of preliminary estimates, corrections, or other reasons. In addition, FDA may change the type or amount of data provided on this website at any time. Information marked as "Completed" may include measures and/or key projects for which activities are ongoing but no longer tracked as part of FDA-TRACK.