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U.S. Department of Health and Human Services

About FDA

Acrylamide, Glycidamide, and Furan Quantitative Assessments

Description: Quantitative assessment of the carcinogenic risks associated with dietary exposure to acrylamide and furan, contaminates found in certain foods cooked at high temperatures. These studies are supported by an interagency agreement between National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP) and FDA to support studies of mutual benefit to FDA and NIEHS/National Institute of Health (NIH).

Definition: Acrylamide and furan are heat-induced food contaminants that may be carcinogenic to humans. These substances are being assessed to determine the effects of exposure to humans. These studies will lead to a better understanding of mechanisms that contribute to a contaminant’s toxicity and the relationship to levels of exposure.

Public Health Outcome: These assessments will determine the carcinogenic risks of acrylamide and furan which will be used to prepare risk assessments for exposure to these chemicals at levels encountered in human food.

1. Acrylamide and Glycidamide Quantitative Assessments

Accomplishment: Acrylamide, a component of various coffees and baked/fried foods, was shown to cause several dose-related carcinogenic features. As dose concentration was increased, an increase in tumor formation, enlargement of various glands, and weight loss increased.

Milestone DescriptionMilestone DateMilestone StatusMilestone Completion Date

a. Prepare draft NCTR report on acrylamide bioassays

5/31/2010

(7/30/2010)

Completed 7/30/2010

b. Compile initial results on carcogenic mutations in tumor tissues from acrylamide bioassays

6/30/2010

(1/1/2011)

(12/30/2011)

(TBD)

Completed FY12 Q2

c. Submit final pathology report on glycidamide to principal investigator

12/31/2010

Completed 6/7/2011

d. Present technical report on acrylamide bioassay to NTP Technical Report Review Committee

1/1/2011

(4/30/2011)

Completed 4/5/2011

e. Prepare draft NCTR report on glycidamide bioassay

4/1/2011

(12/30/2011)

(TBD)

Completed 7/31/2012

f. Present technical report on glycidamide bioassay to NTP Technical Report Review Committee

FY13 Q3

Completed 8/9/2013

Footnotes

  • The dates in italics under the milestone due dates are modified milestone due dates which had to be updated due to real-time delays. The milestone status reflects the revised dates.

2. Furan Quantitative Assessment

Briefing Status: DELAYED

Prior Briefing Status: DELAYED

Milestone DescriptionMilestone DateMilestone StatusMilestone Completion Date

a. Complete an interim 36-week analysis of rodents as part of a 2-year biological assay to determine the toxic effects of the food contaminant furan (Scheduled 5/2010 - 9/2010)

9/1/2010

Completed 9/1/2010

b. Complete an interim 60-week analysis of rodents as part of a 2-year biological assay to determine the toxic effects of the food contaminant furan (Scheduled 11/2010 - 3/2011)

3/1/2011

Completed 3/7/2011

c. Complete an interim 60-week analysis of rodents as part of a 2-year biological assay to determine the toxic effects of the food contaminant furan (Scheduled 9/2011 - 1/2012)

1/1/2012

Completed 1/1/2012

d. Draft pathology report & in-life statistic report

7/1/2012

(FY13 Q1)

Completed 3/4/2013

e. Complete pathology working group review

2/1/2013

(FY13 Q2)

Completed 8/29/2013

f. Finalize pathology statistics report

5/1/2013

(FY13 Q3)

Delayed

g. Prepare draft NCTR final report on furan bioassay

12/1/2013

(FY14 Q1)

Delayed

h. Present technical report on furan bioassay to NTP Technical Report Review Board

TBD

Not Yet Started

Footnotes

  • The dates in italics under the milestone due dates are modified milestone due dates which had to be updated due to real-time delays. The milestone status reflects the revised dates.

Key Projects Legend

Milestone StatusDefinition
Not Yet StartedWork for specific milestone has not yet been started.
CompletedMilestone and/or overall project is completed.
On TrackMilestone - On track for completion by milestone deadline. Quarter status - Project is on track for completion based on overall milestone status.
On HoldMilestone - On hold, but deadline for completion has not passed. Quarter status - Project is on hold, based on overall milestone status.
DelayedMilestone - Delayed as it has not been completed and deadline has passed. Quarter status - Project is delayed based on overall milestone status.

Glossary

Note: The data provided on this website is produced on an ongoing basis for performance management purposes and is subject to change due to updates of preliminary estimates, corrections, or other reasons. In addition, FDA may change the type or amount of data provided on this website at any time. Information marked as "Completed" may include measures and/or key projects for which activities are ongoing but no longer tracked as part of FDA-TRACK.