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U.S. Department of Health and Human Services

About FDA

Alternative Approaches to Antibiotic Therapy for the Prevention and Treatment of Bacterial Infections

Description: Identify biologically active substances that have efficacy to treat or prevent the development of severe infections.

Definition: Antibiotic resistance developed from agribusiness use of antibiotics in the food chain is a continuing problem. NCTR research includes the evaluation of the incidence and mechanisms of drug resistance.

As FDA sets antimicrobial drug-residue limits in animal products, this knowledge can be used to assist the agency to establish better strategies for antibiotic use. This information can also be used to help determine the contribution of different antimicrobials used in the food-production environment to the spread of multi-drug resistance and increased virulence of foodborne pathogens, and can be used to aid risk assessments.

Public Health Outcome: These studies will help address the need of alternative approaches to deal with multidrug resistant pathogens.

Milestone DescriptionMilestone DateMilestone StatusMilestone Completion Date

1. Develop a comprehensive protein database for pathogenic Staphylococcus aureus (S. aureus) isolates



Completed 7/31/2010

2. Identify proteins from S. aureus that may be involved in virulence and pathogenicity



Completed 8/31/2010

3. Examine the role of hyaluronidases as a potential virulence factors in S. aureus




Completed 9/30/2011

4. Complete the assessment of research findings



Completed 10/15/2011

5. Develop draft technical report/manuscript/publication



Completed 7/31/2011

6. Complete the peer review (NCTR and other researchers) of draft technical report, manuscript, and/or publication


Completed 7/31/2011

7. Obtain NCTR Center Director approval on the draft technical report, manuscript, and/or publication via the document tracking system


Completed 7/31/2011

8. Submit final technical report, manuscript and/or publication to a scientific journal


Completed 6/30/2012

Key Projects Legend

Milestone StatusDefinition
Not Yet StartedWork for specific milestone has not yet been started.
CompletedMilestone and/or overall project is completed.
On TrackMilestone - On track for completion by milestone deadline. Quarter status - Project is on track for completion based on overall milestone status.
On HoldMilestone - On hold, but deadline for completion has not passed. Quarter status - Project is on hold, based on overall milestone status.
DelayedMilestone - Delayed as it has not been completed and deadline has passed. Quarter status - Project is delayed based on overall milestone status.


S. aureus

most common cause of staph infections


ability of a pathogen to cause disease


family of enzymes that degrade hyaluronic acid increasing tissue permeability and may help bacterial cells spread from their primary site of infection

Note: The data provided on this website is produced on an ongoing basis for performance management purposes and is subject to change due to updates of preliminary estimates, corrections, or other reasons. In addition, FDA may change the type or amount of data provided on this website at any time. Information marked as "Completed" may include measures and/or key projects for which activities are ongoing but no longer tracked as part of FDA-TRACK.