About FDA
Office of Women’s Health Research Projects
Description: Conduct research to identify solutions to women’s health issues.
Definition: These studies will address issues related to metabolism of colorants in cosmetics by bacteria on the skin and the characterization of probiotics for the prevention of TSS and vaginal yeast infections. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit of the host. TSS is a very rare but potentially fatal illness caused by bacterial toxin. Understanding how probiotics may lead to the prevention of TSS and vaginal yeast infections will reduce the number of these cases, thus advancing the health of women.
Public Health Outcome: These studies will address issues related to metabolism of colorants in cosmetics by bacteria on the skin.
Accomplishment: This study contributed to a sound scientific knowledge basis for determining the safety and toxicity of the colorants in cosmetics used by women and provide data for risk assessment of the metabolism of synthetic azo colorants in cosmetics by human skin microflora.
Briefing Status: COMPLETED
Prior Briefing Status: ON TRACK
| Milestone Description | Milestone Date | Milestone Status | Milestone Completion Date |
|---|---|---|---|
|
1. Identify whether the majority of skin bacteria quickly decolorize the azo dyes and determine whether multiple bacterial azoreductases are likely involved in the reduction of the dyes |
9/30/2010 |
Completed | 9/30/2010 |
|
2. Identify metabolites of aromatic amines produced by human skin bacteria from azo dyes |
9/30/2010 |
Completed | 9/30/2010 |
|
3. Evaluate the toxicological effects of azo dyes and their metabolites on the skin bacterium path S. aureus; the most common cause of staph infections which causes toxic shock syndrome |
9/30/2010 |
Completed | 9/30/2010 |
|
4. Complete the assessment of research findings |
6/30/2011 |
Completed | 6/30/2011 |
|
5. Develop draft technical report/manuscript/publication |
9/30/2011 |
Completed | 9/2/2011 |
|
6. Complete the peer review (NCTR and other researchers) of draft technical report, manuscript, and/or publication |
10/31/2011 |
Completed | 10/8/2011 |
|
7. Obtain NCTR Center Director approval on the draft technical report, manuscript, and/or publication via the document tracking system |
10/31/2011 |
Completed | 10/8/2011 |
|
8. Submit final technical report, manuscript and/or publication to a scientific journal |
12/31/2011 |
Completed | 10/8/2011 |
Key Projects Legend
| Milestone Status | Definition |
|---|---|
| Not Yet Started | Work for specific milestone has not yet been started. |
| Completed | Milestone and/or overall project is completed. |
| On Track | Milestone - On track for completion by milestone deadline. Quarter status - Project is on track for completion based on overall milestone status. |
| On Hold | Milestone - On hold, but deadline for completion has not passed. Quarter status - Project is on hold, based on overall milestone status. |
| Delayed | Milestone - Delayed as it has not been completed and deadline has passed. Quarter status - Project is delayed based on overall milestone status. |
Glossary
TSS
toxic shock syndrome
S. aureus
Staphylococcus aureus
Note: The data provided on this website is produced on an ongoing basis for performance management purposes and is subject to change due to updates of preliminary estimates, corrections, or other reasons. In addition, FDA may change the type or amount of data provided on this website at any time. Information marked as "Completed" may include measures and/or key projects for which activities are ongoing but no longer tracked as part of FDA-TRACK.
