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PhishPharm - Detail

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Title:  Drug uptake and disposition in fish: An autoradiographic study with dihydrostreptomycin in the rainbow trout.
Authors:  Czerwinska K, Sunk RB, Sognen E
Drug:  Dihydrostreptomycin
Fish species:  Trout, rainbow
Date:  1990
Sample:  intestinal tract-stomach
Ave Weight (gm):  100
Ave Water temp (°C):  6
Water:  Freshwater
Dosage:  10 mg sd
Route:  PO
Comments:  At 6 hr - high activity in intestine and some in blood, liver, kidney, gills and eyes but not muscle. By 24 h - increased activity in blood, liver and kidney and base of dorsal fin, highest activity in GI. 48 hr-72 hr most in distal intestine. At 7 days kidney and liver were still active with GI still highest, continuing through 3 wks (3H)DHS.
Citation:  Acta Pharmaceutica Nordica 2:6:377-386
Link:  http://www.cabdirect.org/abstracts/19912216788.html  Opens a new window
Genus Species:  Oncorhynchus mykiss
Drug Class:  Antibiotic-Aminoglycoside
Wt gm-detail:  100 g
Water temp (°C)-detail:  5.5-6 C
Dosage-detail:  10 mg sd
Method:  Rad/Whole body Autoradiography
Authors-red:  Czerwinska K, Sunk RB, Sognen E