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Title:
Depletion of chloramphenicol in trout after a hypothetic therapeutic treatment.
Authors:
Biancotto G, Contiero L, Benetti C, Calligaris M, Tibaldi E, Cerni L, Francese L
Drug:
Chloramphenicol
Fish species:
Trout, rainbow
Date:
2009
Sample:
muscle
Ave Weight (gm):
374
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
80 mg/kg 10 d
Route:
PO
Comments:
Triploid rainbow trout were used. Chloramphenicol(CAP) mean concentration 0d post-dose=35781 ug/kg, 2d post-dose=2306 ug/kg, 3d post-dose=2112 ug/kg, 4d post-dose=837 ug/kg, 9d post-dose=43 ug/kg, 16d post-dose=12.7 ug/kg, 24d post-dose=1.04 ug/kg, 31d post-dose=0.32 ug/kg. CAP was observed in high concentrations (1ug/kg+) for up to day four post dose, after which it was eliminated rapidly through day 31.
Citation:
Analytica Chimica Acta 637:173-177
Link:
http://dx.doi.org/10.1016/j.aca.2008.09.065
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Phenicol
Wt gm-detail:
Individual mean=374 g, Range=300-550g.
Water temp (°C)-detail:
12.2+/-0.19C
Dosage-detail:
80 mg/kg 10d (Recalculated back as 73.9 mg/kg 10 d)
Method:
HPLC/MSMS
Authors-red:
Biancotto G, Contiero L, Benetti C, Calligaris M, Tibaldi E, Cerni L, Francese L
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