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U.S. Department of Health and Human Services

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Title:  Depletion of chloramphenicol in trout after a hypothetic therapeutic treatment.
 
Authors:  Biancotto G, Contiero L, Benetti C, Calligaris M, Tibaldi E, Cerni L, Francese L
 
Drug:  Chloramphenicol
 
Fish species:  Trout, rainbow
 
Date:  2009
 
Sample:  muscle
 
Ave Weight (gm):  374
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  80 mg/kg 10 d
 
Route:  PO
 
Comments:  Triploid rainbow trout were used. Chloramphenicol(CAP) mean concentration 0d post-dose=35781 ug/kg, 2d post-dose=2306 ug/kg, 3d post-dose=2112 ug/kg, 4d post-dose=837 ug/kg, 9d post-dose=43 ug/kg, 16d post-dose=12.7 ug/kg, 24d post-dose=1.04 ug/kg, 31d post-dose=0.32 ug/kg. CAP was observed in high concentrations (1ug/kg+) for up to day four post dose, after which it was eliminated rapidly through day 31.
 
Citation:  Analytica Chimica Acta 637:173-177
 
Link:  http://dx.doi.org/10.1016/j.aca.2008.09.065  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Phenicol
 
Wt gm-detail:  Individual mean=374 g, Range=300-550g.
 
Water temp (°C)-detail:  12.2+/-0.19C
 
Dosage-detail:  80 mg/kg 10d (Recalculated back as 73.9 mg/kg 10 d)
 
Method:  HPLC/MSMS
 
Authors-red:  Biancotto G, Contiero L, Benetti C, Calligaris M, Tibaldi E, Cerni L, Francese L
 
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