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Title:
Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin in Atlantic salmon (Salmo salar) held in seawater at 10 oC.
Authors:
Martinsen B, Horsberg TE
Drug:
Flumequine
Fish species:
Salmon, Atlantic
Date:
1995
t1/2-hr:
23
Sample:
blood, plasma
Ave Weight (gm):
240
Ave Water temp (°C):
10
Water:
Saltwater
Dosage:
25 mg/kg sd
Route:
IV
Comments:
Residues = 3 h=9.51, 6 h= 5.46, 12 h = 3.11, 24 h= 1.15, 48 h= 0.55, 72 h= 0.25, 120 = 0.06 ug/g.
Cl:
0.18 L/kg/h
Vd:
3.5 L/kg
Citation:
Antimicrobial Agents and Chemotherapy 39:1059-1064
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7625789&dopt=Abstract
Genus Species:
Salmo salar
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
22.8 h
Wt gm-detail:
240 +/- 50 g
Water temp (°C)-detail:
10.2 +/- 0.2 C
Dosage-detail:
25 mg/kg sd
Method:
HPLC
Authors-red:
Martinsen B, Horsberg TE
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