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U.S. Department of Health and Human Services

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Title:  Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin in Atlantic salmon (Salmo salar) held in seawater at 10 oC.
 
Authors:  Martinsen B, Horsberg TE
 
Drug:  Oxolinic acid
 
Fish species:  Salmon, Atlantic
 
Date:  1995
 
t1/2-hr:  48
 
est:  est
 
Sample:  blood, plasma
 
Ave Weight (gm):  240
 
Ave Water temp (°C):  10
 
Water:  Saltwater
 
Dosage:  25 mg/kg sd
 
Route:  PO
 
Comments:  Bioavailability =30.1%. Residues 3 h= 0.18, 12 h= 0.61, 48h = 0.24, 72 h= 0.11, 120 h = 0.01 ug/g.
 
Cl:  0.28 L/kg/h
 
Vd:  5.4 L/kg
 
Citation:  Antimicrobial Agents and Chemotherapy 39:1059-1064
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7625789&dopt=Abstract  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  48 hr est
 
Wt gm-detail:  240 +/- 50 g
 
Water temp (°C)-detail:  10.2 +/- 0.2 C
 
Dosage-detail:  25 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Martinsen B, Horsberg TE
 
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