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Title:
Pharmacokinetics and bioavailability of flumequine and oxolinic acid after various routes of administration to Atlantic salmon in seawater.
Authors:
Rogstad A, Ellingsen OF, Syvertsen C
Drug:
Flumequine
Fish species:
Salmon, Atlantic
Date:
1993
t1/2-hr:
23
Sample:
blood, plasma
Ave Weight (gm):
425
Ave Water temp (°C):
5
Water:
Saltwater
Dosage:
4.9 mg/kg sd
Route:
IV
Comments:
Salinity 30ppt. Residues 0.5h=4.9, 1h=3.8, 2h=2.8, 4h=1.6, 6h=1.1, 8h=0.9,12h=0.8, 24h=0.5, 48h=0.3, 72h=0.2, 96h=0.2 ug/ml. AUC=46.5 ug h/ml. T 1/2 alpha 1.3h
Cl:
0.095 L/kg/h
Vc:
0.8 L/kg
Vd:
3.1 L/kg
Citation:
Aquaculture 110:207-220
Link:
http://www.sciencedirect.com/science/article/pii/004484869390369A
Genus Species:
Salmo salar
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
23+/-5 h
Wt gm-detail:
425 g
Water temp (°C)-detail:
5+/-0.2 C
Dosage-detail:
4.9 mg/kg sd
Method:
HPLC
Authors-red:
Rogstad A, Ellingsen OF, Syvertsen C
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