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U.S. Department of Health and Human Services

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Title:  Single dose kinetic study of sarafloxacin after intravascular and oral administration to cannulated Atlantic salmon (Salmo salar) held in sea water at 12 C.
 
Authors:  Martinsen B, Sohlberg S, Horsberg T E, Burke M
 
Drug:  Sarafloxacin
 
Fish species:  Salmon, Atlantic
 
Date:  1993
 
t1/2-hr:  46
 
Sample:  blood, plasma
 
Ave Weight (gm):  932
 
Ave Water temp (°C):  12
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  Cannulated fish, salinity 26-32%. Hematocrit was about 20 % of non-cannulated fish, with a futher drop of 25% after drug administration/sampling. ACU mean of four fish 52.5 ug*h/ml. t 1/2 alpha = 1.44 h.
 
Cl:  0.22 L/kg/h
 
Vd:  13.6 L/kg
 
Citation:  Aquaculture 118:49-52
 
Link:  http://dx.doi.org/10.1016/0044-8486(93)90279-8   Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  45.3 h
 
Wt gm-detail:  932 +/-172g
 
Water temp (°C)-detail:  12+/-1.5 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Martinsen B, Sohlberg S, Horsberg T E, Burke M
 
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