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Title:
Distribution and elimination of [14C]sarafloxacin hydrochloride from tissues of juvenile channel catfish (Ictalurus punctatus).
Authors:
Gingerich WH, Meinertz JR, Dawson VK, Gofus JE, Delaney LJ, Bunnell PR
Drug:
Sarafloxacin
Fish species:
Catfish, channel
Date:
1995
t1/2-hr:
9
Sample:
muscle
Ave Weight (gm):
50
Ave Water temp (°C):
25
Water:
Freshwater
Dosage:
10 mg/kg 5 d
Route:
PO
Comments:
Highest mean concentration of parent-equivalent material found 12 h after last dose, Half life determined by radioactive counting=9.33 h, by fluorometric method t 1/2 = 8.89 h. The gamma phase t 1/2 = 185 h. Sarafloxacin (C14). oral gavage. Residues (ng/g) 3h=1711, 12 hr = 2268, 48 h = 359. 240 h=8.1.
Citation:
Aquaculture 131:23-36
Link:
http://dx.doi.org/10.1016/0044-8486(94)00362-R
Genus Species:
Ictalurus punctatus
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
8.9 h
Wt gm-detail:
38.4-62.0 g
Water temp (°C)-detail:
24.8+/-0.5 C
Dosage-detail:
9.82 mg/kg+/-0.71
Method:
HPLC-Rad
Authors-red:
Gingerich WH, Meinertz JR, Dawson VK, Gofus JE, Delaney LJ, Bunnell PR
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