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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and metabolism of sulphamonomethoxine in rainbow trout (Oncorhynchus mykiss) and yellowtail (Seriola quinqueradiata) following bolus intravascular administration.
 
Authors:  Uno K, Aoki T, Ueno R, Maeda I
 
Drug:  Sulfamonomethoxine
 
Fish species:  Amberjack, Japanese (yellowtail)
 
Date:  1997
 
t1/2-hr:  6
 
Sample:  blood, serum
 
Ave Weight (gm):  638
 
Ave Water temp (°C):  21
 
Water:  Saltwater
 
Dosage:  100 mg/kg sd
 
Route:  IV
 
Comments:  Protein binding for AcSMM= 6.3 +/- 2.3% Vd= 0.56 L/kg; Vc= 0.3 L/kg alpha=0.53h.
 
Protein binding:  5.8 +/- 1.7%
 
Cl:  0.067 L/kg/h
 
Vc:  0.3 L/kg
 
Vd:  0.56 L/kg
 
Metabolites:  N4-A-sulphamonomethoxine
 
Citation:  Aquaculture 153:1-8
 
Link:  http://dx.doi.org/10.1016/S0044-8486(97)00012-4  Opens a new window
 
Genus Species:  Seriola quinqueradiata
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  5.8 h
 
Wt gm-detail:  638 +/- 68 g
 
Water temp (°C)-detail:  21.3 +/- 0.2 C
 
Dosage-detail:  100 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Uno K, Aoki T, Ueno R, Maeda I
 
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