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Title:
Pharmacokinetics and metabolism of sulphamonomethoxine in rainbow trout (Oncorhynchus mykiss) and yellowtail (Seriola quinqueradiata) following bolus intravascular administration.
Authors:
Uno K, Aoki T, Ueno R, Maeda I
Drug:
Sulfamonomethoxine
Fish species:
Trout, rainbow
Date:
1997
t1/2-hr:
31
Sample:
blood, serum
Ave Weight (gm):
171
Ave Water temp (°C):
15
Water:
Freshwater
Dosage:
100 mg/kg sd
Route:
IV
Comments:
protein binding for AcSMM= 9.5 +/- 3.6% Vd= 0.83 L/kg; Vc= 0.3 L/kg, alpha = 0.43h.
Protein binding:
6.4 +/- 2.3%
Cl:
0.0185 L/kg/h
Vc:
0.3 L/kg
Vd:
0.83 L/kg
Metabolites:
N4-A-sulphamonomethoxine
Citation:
Aquaculture 153:1-8
Link:
http://dx.doi.org/10.1016/S0044-8486(97)00012-4
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
30.9 h
Wt gm-detail:
171 +/- 15 g
Water temp (°C)-detail:
15.0 +/- 0.3 C
Dosage-detail:
100 mg/kg sd
Method:
HPLC
Authors-red:
Uno K, Aoki T, Ueno R, Maeda I
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