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Title:
Single dose pharmacokinetic study of flumequine after intravenous, intraperitoneal and oral administration to Atlantic halibut (Hippoglossus hippoglossus) held in seawater at 9oC.
Authors:
Samuelsen OB, Ervik A (1997)
Drug:
Flumequine
Fish species:
Halibut, Atlantic
Date:
1997
t1/2-hr:
43
Sample:
blood, plasma
Ave Weight (gm):
2000
Ave Water temp (°C):
9
Water:
Saltwater
Dosage:
12 mg/kg sd
Route:
IV
Comments:
t 1/2 '²= 7 +/- 2 h, ³ = 43 +/- 8 h. Residue peak at 3 h= 7.92, 12 h = 3.92, 24 h = 2.28, 96 h= 0.38, 240 = 0.15 ug/ml.
Cl:
0.052 L/kg/h
Vd:
2.3 L/kg
Metabolites:
7-hydroxy-flumequine
Citation:
Aquaculture 158:215-227
Link:
http://dx.doi.org/10.1016/S0044-8486(97)00190-7
Genus Species:
Hippoglossus hippoglossus
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
²= 7 +/- 2 h³ = 43 +/- 8 h
Wt gm-detail:
1.5- 2.5 kg
Water temp (°C)-detail:
9 C
Dosage-detail:
12 mg/kg sd
Method:
HPLC
Authors-red:
Samuelsen OB, Ervik A (1997)
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