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Title:
Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and Chinook salmon.
Authors:
Abedini S, Namdari R, Law FCP
Drug:
Oxytetracycline
Fish species:
Salmon, chinook
Date:
1998
t1/2-hr:
88
Sample:
blood
Ave Weight (gm):
350
Ave Water temp (°C):
11
Water:
Saltwater
Dosage:
50 mg/kg sd
Route:
IVC
Comments:
Lower Vd than expected in both spp, maybe because implanted cannula; bioavailability of OTC after PO are 24.84% (salmon) and 30.30% (trout) which are higher than normal; Vd= 0.89 l/kg - Chinook in seawater. OTC conc in blood went from 1000 ug/ml to approx 8 ug/ml in first 200 h, down to 1 by 900 h. AUC= 7126.8 ug h/ml
Vd:
0.89 L/kg
Citation:
Aquaculture 162:23-32
Link:
http://dx.doi.org/10.1016/S0044-8486(97)00306-2
Genus Species:
Oncorhynchus tshawytscha
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
88.29 h
Wt gm-detail:
350 g
Water temp (°C)-detail:
11 C
Dosage-detail:
50 mg/kg sd
Method:
HPLC
Authors-red:
Abedini S, Namdari R, Law FCP
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