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U.S. Department of Health and Human Services

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Title:  Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and Chinook salmon.
Authors:  Abedini S, Namdari R, Law FCP
Drug:  Oxytetracycline
Fish species:  Salmon, chinook
Date:  1998
t1/2-hr:  88
Sample:  blood
Ave Weight (gm):  350
Ave Water temp (°C):  11
Water:  Saltwater
Dosage:  50 mg/kg sd
Route:  IVC
Comments:  Lower Vd than expected in both spp, maybe because implanted cannula; bioavailability of OTC after PO are 24.84% (salmon) and 30.30% (trout) which are higher than normal; Vd= 0.89 l/kg - Chinook in seawater. OTC conc in blood went from 1000 ug/ml to approx 8 ug/ml in first 200 h, down to 1 by 900 h. AUC= 7126.8 ug h/ml
Vd:  0.89 L/kg
Citation:  Aquaculture 162:23-32
Link:  http://dx.doi.org/10.1016/S0044-8486(97)00306-2  Opens a new window
Genus Species:  Oncorhynchus tshawytscha
Drug Class:  Antibiotic-Tetracycline
t1/2-detail:  88.29 h
Wt gm-detail:  350 g
Water temp (°C)-detail:  11 C
Dosage-detail:  50 mg/kg sd
Method:  HPLC
Authors-red:  Abedini S, Namdari R, Law FCP