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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of oxytetracycline in Arctic charr (Salvelinus alpinus L.) in freshwater at low temperature.
 
Authors:  Haug T, Hals PA
 
Drug:  Oxytetracycline
 
Fish species:  Char, Arctic
 
Date:  2000
 
t1/2-hr:  468
 
Sample:  blood, plasma
 
Ave Weight (gm):  707
 
Ave Water temp (°C):  6
 
Water:  Freshwater
 
Dosage:  100 mg/kg sd
 
Route:  PO
 
Comments:  OTC dissolved in liposome/alginate dosed by gavage under MS222. The mean maximum concentration of OTC in plasma was significantly higher in the group receiveing OTC in agar compared to the OTC dissolved in liposome/alginate dosed by gavage under MS222. group. Mean time to reach Cmax was longer in the liposome/alginate group, 136h, vs the agar group, 17.8 h. Max 0.97 ug/ml. Bioavail 3.2 %. AUC = 510 ug h/ml. Cannulated fish.
 
Citation:  Aquaculture 186:175-191
 
Link:  http://dx.doi.org/10.1016/S0044-8486(99)00376-2  Opens a new window
 
Genus Species:  Salvelinus alpinus alpinus
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  468.5+/-85.1 h
 
Wt gm-detail:  707+/-107 g
 
Water temp (°C)-detail:  4.2-8.6 C
 
Dosage-detail:  100 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Haug T, Hals PA
 
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