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Title:
Poor bioavailability of oxytetracycline in sharpsnout sea bream Diplodus puntazzo.
Authors:
Rigos G, Tyrpenou AE, Nengas I, Alexis AEM, Athanassopoulou, Troisi GM
Drug:
Oxytetracycline
Fish species:
Seabream, sharpsnout
Date:
2004
t1/2-hr:
35
Sample:
blood, plasma
Ave Weight (gm):
90
Ave Water temp (°C):
19
Water:
Saltwater
Dosage:
40 mg/kg sd
Route:
IV
Comments:
Salt water 36 ppt. AUC = 549 ug/h ml. Residues ug/ml 1h=18.6, 2h=14.1, 4h=12.4, 8h=9.9, 16h=7.7, 24h=5.8, 48h=4.0, 72h=1.6, 150h=0.9.
Cl:
0/08L/kg/h
Vc:
1.7+/-0.03 L/kg
Vd:
4 L/kg
Citation:
Aquaculture 235:489-497
Link:
http://dx.doi.org/10.1016/j.aquaculture.2003.10.016
Genus Species:
Diplodus puntazzo
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
1.4 alpha, 34.5+/-3 h beta
Wt gm-detail:
90+/-20 g
Water temp (°C)-detail:
19+/-0.5 C
Dosage-detail:
40 mg/kg sd
Method:
HPLC
Authors-red:
Rigos G, Tyrpenou AE, Nengas I, Alexis AEM, Athanassopoulou, Troisi GM
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