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U.S. Department of Health and Human Services

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Title:  Comparative pharmacokinetics of oxytetracycline in eel and its fate in a closed aquatic environment.
 
Authors:  Ueno R, Kinoshita A, Wakabayashi J
 
Drug:  Oxytetracycline
 
Fish species:  Eel, Japanese
 
Date:  2004
 
t1/2-hr:  96
 
est:  est
 
Sample:  blood, serum
 
Ave Weight (gm):  158
 
Ave Water temp (°C):  27
 
Water:  Not specified
 
Dosage:  50 mg/kg 6 d
 
Route:  PO
 
Comments:  Pond fish. Bioavailability=0.69%. OTC C-max 0.64 ug/ml reached 1 day after last medication and not detected at 7 d after last medication. Sediment OTC levels decreased rapidly and nd after 27d. Water OTC during medicaiton (0.23-0.27 ug/ml) declined and nd by 5 days post medication.
 
Citation:  Aquaculture 235:53-63
 
Link:  http://dx.doi.org/10.1016/S0044-8486(03)00449-6  Opens a new window
 
Genus Species:  Anguilla japonica
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  96 h est
 
Wt gm-detail:  158 g
 
Water temp (°C)-detail:  27 C
 
Dosage-detail:  50 mg/kg for 6 d
 
Method:  HPLC
 
Authors-red:  Ueno R, Kinoshita A, Wakabayashi J
 
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