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U.S. Department of Health and Human Services

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Title:  Florfenicol residue depletion in channel catfish, Ictalurus punctatus (Rafinesque).
 
Authors:  Wrzesinski C, Crouch L, Gaunt P, Holifield D, Bertrand N, Endris D.
 
Drug:  Florfenicol
 
Fish species:  Catfish, channel
 
Date:  2006
 
t1/2-hr:  48
 
est:  est
 
Sample:  muscle
 
Ave Weight (gm):  920
 
Ave Water temp (°C):  19
 
Water:  Freshwater
 
Dosage:  10 mg/kg 10 d*
 
Route:  PO
 
Comments:  Dose: fish fed poorly for first two days so the dose was fed for 12 days. Expected dose based on feed consumption 9.3 mg/kg/day for the last 10 days. Residues in male and female fish similar. Mean Residues (ppb) [median in brackets] withdrawal d1=5378 [2684], d2=2303 [831], d4=876 [702], d7=232 [185], d14=168 [142], d21=169 [151]. Samples below LOQ or LOD were not used in calculating average.
 
Metabolites:  Florfenicol amine
 
Citation:  Aquaculture 253:309-316
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2005.05.005  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  48 h est
 
Wt gm-detail:  2.02 llb
 
Water temp (°C)-detail:  ave 20.7C Rx, ave 17.9C WD
 
Dosage-detail:  10 mg/kg 10 d*
 
Method:  HPLC-UV
 
Authors-red:  Wrzesinski C, Crouch L, Gaunt P, Holifield D, Bertrand N, Endris D.
 
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