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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and tissue residues of difloxacdin in crucian carp (Crassius auratus) after oral administration.
 
Authors:  Ding F, Cao J, Ma L, Pan Q, Fang Z, Lu X
 
Drug:  Difloxacin
 
Fish species:  Carp, crucian (goldfish)
 
Date:  2006
 
t1/2-hr:  95
 
Sample:  blood, plasma
 
Ave Weight (gm):  250
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  20 mg/kg sd
 
Route:  PO
 
Comments:  AUC=1361.79 ug/mlh, time to peak 5.7 h, Cmax=9.49. Ka (absorption rate constant =0.85/h.
 
Cl:  0.015 l/h/kg
 
Vd:  2.02 l/kg
 
Citation:  Aquaculture 256:121-128
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2006.02.056  Opens a new window
 
Genus Species:  Carassius auratus auratus
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  95
 
Wt gm-detail:  250 +/-30g
 
Water temp (°C)-detail:  10 +/-1 C
 
Dosage-detail:  20 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Ding F, Cao J, Ma L, Pan Q, Fang Z, Lu X
 
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