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U.S. Department of Health and Human Services

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Title:  The biopharmaceutics and oral bioavailability of two forms of oxytetracycline to the white shrimp, Litopenaeus setiferus.
 
Authors:  Reed LA, Siewicki TC, Shah JC
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, northern white
 
Date:  2006
 
t1/2-hr:  48
 
est:  est
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  23
 
Ave Water temp (°C):  21
 
Water:  Saltwater
 
Dosage:  45 mg/kg BID 14 d
 
Route:  PO
 
Comments:  Tested OTC dihydrate formulation. 2x more soluble than quaternary salt form. Salinity=20ppt. Dose calculated using avg wt of 23 g and 2% bw per day. T1/2 used from previous work to develop model. Vd=Vc+Vp. t1/2-hr extrapolated from curve.
 
Vc:  715 mL/kg
 
Vd:  2310 mL/kg
 
Citation:  Aquaculture 258:42-54
 
Dep-time:  14 d
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2006.03.029  Opens a new window
 
Genus Species:  Litopenaeus setiferus
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  48 h est
 
Wt gm-detail:  14.92-31.44g
 
Water temp (°C)-detail:  20+/-2 C
 
Dosage-detail:  45 mg/kg 14 d Q12h
 
Method:  HPLC
 
Authors-red:  Reed LA, Siewicki TC, Shah JC
 
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