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U.S. Department of Health and Human Services

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Title:  Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi.
 
Authors:  Tubbs L, Tingle M
 
Drug:  Praziquantel
 
Fish species:  Amberjack, yellowtail (kingfish)
 
Date:  2006
 
t1/2-hr:  24
 
est:  est
 
Sample:  skin
 
Ave Weight (gm):  500
 
Ave Water temp (°C):  19
 
Water:  Saltwater
 
Dosage:  150 mg/kg 3d*
 
Route:  PO
 
Comments:  Oral intubation in DMSO solution, used in Japan. 2.4 higher than low dose. Max conc 8-11 ug/g, min approx 1 every 24 hr. t 1/2 est from graph.
 
Citation:  Aquaculture 261:1168-1174
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2006.09.013  Opens a new window
 
Genus Species:  Seriola lalandi
 
Drug Class:  Antiparasitic-Praziquantel
 
t1/2-detail:  24 est
 
Wt gm-detail:  400-600 g
 
Water temp (°C)-detail:  18-19 C
 
Dosage-detail:  150 mg/kg 3d*
 
Method:  HPLC
 
Authors-red:  Tubbs L, Tingle M.
 
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