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Title:
Pharmacokinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in Scylla serrata following oral gavage at two salinities.
Authors:
Fang WH, Zhou S, Yu HJ, Hu LL, Zhou K, Liang SC
Drug:
Enrofloxacin
Fish species:
Crab, mud
Date:
2007
t1/2-hr:
65
Sample:
blood, hemolymph
Ave Weight (gm):
140
Ave Water temp (°C):
25
Water:
Freshwater
Dosage:
30 mg/kg sd
Route:
PO
Comments:
T1/2 field=parent. Cmax=30.53 ug/ml, Tmax=2h, Salinity 4 ppt, AUC=1628.6 ug/h/ml.
Cl:
0.018
Vd:
1.73
Metabolites:
Ciprofloxacin
Citation:
Aquaculture 272:180-187
Link:
http://dx.doi.org/10.1016/j.aquaculture.2007.08.049
Genus Species:
Scylla serrata
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
65.09
Wt gm-detail:
120-160 g
Water temp (°C)-detail:
25 +/- 1 C
Dosage-detail:
Single dose of 0.5 ml/kg at 60 g/L corresponding to 30mg/kg
Method:
HPLC
Authors-red:
Fang WH, Zhou S, Yu HJ, Hu LL, Zhou K, Liang SC
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