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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O.caureus) after a single oral administration in freshwater and seawater at 28 C.
 
Authors:  Feng JB, Jia XP, Li LD.
 
Drug:  Florfenicol
 
Fish species:  Tilapia (hybrid)
 
Date:  2008
 
t1/2-hr:  8
 
Sample:  Muscle
 
Ave Weight (gm):  115
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  10 mg/Kg sd
 
Route:  PO
 
Comments:  Cmax = 4.59ug/g Tmax=12 hrs ; 1.6ug/g after 24hrs. During later sampling times (12-168 h) concentrations of florfenicol were ususally higher in freshwater tilapia than in seawater. Florfenicol residues, estimated from graph: 2h= 1.5 ug/g, 4h= 1.5 ug/g, 6h= 0.5 ug/g, 8h= 2.5, 10h= 1, 12h=5, 18h= 2, 24h= 2, 48h= <0.25.
 
Metabolites:  Florfenicol amine
 
Citation:  Aquaculture 276:29-35
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.01.002  Opens a new window
 
Genus Species:  Oreochromis niloticus x O. aureus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  8.03hr
 
Wt gm-detail:  115 g
 
Water temp (°C)-detail:  28 +/- 1 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Feng JB, Jia XP, Li LD.
 
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