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Title:
Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O.caureus) after a single oral administration in freshwater and seawater at 28 C.
Authors:
Feng JB, Jia XP, Li LD.
Drug:
Florfenicol
Fish species:
Tilapia (hybrid)
Date:
2008
t1/2-hr:
8
Sample:
Muscle
Ave Weight (gm):
115
Ave Water temp (°C):
28
Water:
Freshwater
Dosage:
10 mg/Kg sd
Route:
PO
Comments:
Cmax = 4.59ug/g Tmax=12 hrs ; 1.6ug/g after 24hrs. During later sampling times (12-168 h) concentrations of florfenicol were ususally higher in freshwater tilapia than in seawater. Florfenicol residues, estimated from graph: 2h= 1.5 ug/g, 4h= 1.5 ug/g, 6h= 0.5 ug/g, 8h= 2.5, 10h= 1, 12h=5, 18h= 2, 24h= 2, 48h= <0.25.
Metabolites:
Florfenicol amine
Citation:
Aquaculture 276:29-35
Link:
http://dx.doi.org/10.1016/j.aquaculture.2008.01.002
Genus Species:
Oreochromis niloticus x O. aureus
Drug Class:
Antibiotic-Phenicol
t1/2-detail:
8.03hr
Wt gm-detail:
115 g
Water temp (°C)-detail:
28 +/- 1 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Feng JB, Jia XP, Li LD.
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