Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Common Links
  • Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail
  • Print
  • Share
  • E-mail
-
 
Title:  Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O.caureus) after a single oral administration in freshwater and seawater at 28 C.
 
Authors:  Feng JB, Jia XP, Li LD.
 
Drug:  Florfenicol
 
Fish species:  Tilapia (hybrid)
 
Date:  2008
 
t1/2-hr:  22
 
Sample:  Bile
 
Ave Weight (gm):  115
 
Ave Water temp (°C):  28
 
Water:  Freshwater
 
Dosage:  10 mg/Kg sd
 
Route:  PO
 
Comments:  Cmax= 8.57 ug/g Tmax= 24 hrs During later sampling times (12-168 h) concentrations of florfenicol were ususally higher in freshwater tilapia than in seawater. Florfenicol residues, estimated from graph: 2h= 3 ug/g, 4h= 1.75, 6h= 0.25, 8h= 4, 10h= 1.75, 12h= 5, 18h= 4, 24h= 9, 48h= 2, 72h= 6, 96h= <0.25.
 
Metabolites:  Florfenicol amine
 
Citation:  Aquaculture 276:29-35
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.01.002  Opens a new window
 
Genus Species:  Oreochromis niloticus x O. aureus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  21.79hr
 
Wt gm-detail:  115 g
 
Water temp (°C)-detail:  28 +/- 1 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Feng JB, Jia XP, Li LD.
 
-
-