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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Efficacy, tissue distribution, and residue depletion of oxytetracycline in WS-RLP infected California red abalone Haliotis rufescens
 
Authors:  Rosenblum ES, Robbins TT, Scott BB, Nelson S, Juhasz C, Craigmill A, Tjeerdema RS, Moore JD, Friedman CS
 
Drug:  Oxytetracycline
 
Fish species:  Abalone, red
 
Date:  2008
 
t1/2-hr:  538
 
Sample:  digestive gland
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  17
 
Water:  Saltwater
 
Dosage:  104mg/kg 10 d
 
Route:  PO
 
Comments:  All treatment regimes showed significantly more OTC in digestive gland samples relative to foot muscle samples. All treatments led to significant reductions in withering syndrome (WS-RLP) prevalence, muscular atrophy, and mortality. More mortalities were seen in control animals at higher temperature, however more treated animals died at the lower temperature. Post dose concentrations (ppm): 3d=831, 17d=176, 23d=120, 42d=60, 61d=37, 80d=9, 102d=11, 122d=3, 160d=3, 200d=ND. After dosing withdrawal points 42, 81, and 122 days, a group of animals were re-challenged by being placed back into an infected, cohabitant tank for 30 days. PCR suggests animals never exposed to oxytetracycline were significantly more susceptible to infection.
 
Citation:  Aquaculture 277: 138-148
 
Dep-time:  Below 2 ppm tolerance by day 239.
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.03.005  Opens a new window
 
Genus Species:  Haliotis rufescens
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  22.4 d
 
Wt gm-detail:  Not specified
 
Water temp (°C)-detail:  17.3
 
Dosage-detail:  listed as 103.4 mg/kg abalone in abstract, 104mg OTC/kg biomass in paper
 
Method:  Micro
 
Authors-red:  Rosenblum ES, Robbins TT, Scott BB, Nelson S, Juhasz C, Craigmill A, Tjeerdema RS, Moore JD, Friedman CS
 
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