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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Tissue distribution and elimination of norfloxacin in Japanese sea perch (Lateolabras japonicus) and black sea bream (Sparus macrocephalus) following multi-oral administration.
Authors:  Wang Q, Liu Q, Li J, Wang Q
Drug:  Norfloxacin
Fish species:  Seabream, blackhead
Date:  2008
t1/2-hr:  89
Sample:  muscle
Ave Weight (gm):  165
Ave Water temp (°C):  15.7
Water:  Saltwater
Dosage:  30mg/kg/d, 5d
Route:  PO
Comments:  Seawater -30ppt. Mean drug concentration = 3.29ug/g 1d post-dosing. Theoretical withdrawal periods of 32d, 28d and 23d when drug concentrations were 0.01ug/g, 0.02ug/g and 0.05ug/g respectively.
Citation:  Aquaculture 278:1-4
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.03.021  Opens a new window
Genus Species:  Acanthopagrus schlegelii schlegelii
Drug Class:  Antibiotic-Quinolone
t1/2-detail:  3.75d
Wt gm-detail:  150-180g
Water temp (°C)-detail:  15.7+/-1.0
Dosage-detail:  30mg/kg/d for 5d
Method:  HPLC-UV
Authors-red:  Wang Q, Liu Q, Li J, Wang Q