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U.S. Department of Health and Human Services

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Title:  Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 C.
 
Authors:  Feng JB, Jia XP
 
Drug:  Florfenicol
 
Fish species:  Tilapia (hybrid)
 
Date:  2009
 
t1/2-hr:  36
 
Sample:  bile
 
Ave Weight (gm):  98
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  Tmax reached at 12 h. Cmax concentration = 10.87ug/g. Elimination was relatively slow, declining to 0.36 ug/g at 168 h. Tissue:Plasma ratio: 2h=0.5, 4h= 0.4, 6h=0.8, 8h=1.5, 10h= 0.9, 12h=2.4, 18h=2.7, 24h=3.2, 48h=11.6, 72h=22.1, 96h=19.1, 168h=8.2. Range = 0.43-22.07
 
Citation:  Aquaculture 289: 129-133
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2008.12.023  Opens a new window
 
Genus Species:  Oreochromis niloticus x O. aureus
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  36.29 h
 
Wt gm-detail:  98g
 
Water temp (°C)-detail:  22 +/- 1 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Feng JB, Jia XP
 
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