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Title:
Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 C.
Authors:
Feng JB, Jia XP
Drug:
Florfenicol
Fish species:
Tilapia (hybrid)
Date:
2009
t1/2-hr:
36
Sample:
bile
Ave Weight (gm):
98
Ave Water temp (°C):
22
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
PO
Comments:
Tmax reached at 12 h. Cmax concentration = 10.87ug/g. Elimination was relatively slow, declining to 0.36 ug/g at 168 h. Tissue:Plasma ratio: 2h=0.5, 4h= 0.4, 6h=0.8, 8h=1.5, 10h= 0.9, 12h=2.4, 18h=2.7, 24h=3.2, 48h=11.6, 72h=22.1, 96h=19.1, 168h=8.2. Range = 0.43-22.07
Citation:
Aquaculture 289: 129-133
Link:
http://dx.doi.org/10.1016/j.aquaculture.2008.12.023
Genus Species:
Oreochromis niloticus x O. aureus
Drug Class:
Antibiotic-Phenicol
t1/2-detail:
36.29 h
Wt gm-detail:
98g
Water temp (°C)-detail:
22 +/- 1 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Feng JB, Jia XP
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