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U.S. Department of Health and Human Services

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Title:  Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations
 
Authors:  Koc F, Uney K, Atamanalp M, Tumer I, Kaban G
 
Drug:  Enrofloxacin
 
Fish species:  Trout, brown
 
Date:  2009
 
t1/2-hr:  22
 
Sample:  blood, plasma
 
Ave Weight (gm):  170
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  Fish were anestitised with 30 mgL MS-222. Ciprofloxacin was not detected in plasma at any of the time points, 0.08h-120h following administration. Half life alpha=3.0. AUC=55.0. Cmax = 2.30 ug mL, Tmax=8h. The elimination half-life for EF was longer than values calculated for mammalian and avian species, but similar to other fish species. Mean plasma concentration was well above the minimum inhibitory concentrations (>0.5ug/ mL at 36h) for most gram negative fish pathogens.
 
Metabolites:  Ciprofloxacin
 
Citation:  Aquaculture 295: 142-144
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2009.06.004  Opens a new window
 
Genus Species:  Salmo trutta fario
 
Drug Class:  Antibiotic - Quinolone
 
t1/2-detail:  22.09+/- 2.02
 
Wt gm-detail:  170+/-32
 
Water temp (°C)-detail:  10
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC-UV
 
Authors-red:  Koc F, Uney K, Atamanalp M, Tumer I, Kaban G
 
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