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U.S. Department of Health and Human Services

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Title:  Plasma and tissue depletion of florfenicol in olive flounder (Paralichthys olivaceus) after oral administration.
 
Authors:  Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI
 
Drug:  Florfenicol
 
Fish species:  Halibut, bastard
 
Date:  2010
 
t1/2-hr:  38
 
Sample:  blood, plasma
 
Ave Weight (gm):  380
 
Ave Water temp (°C):  19
 
Water:  Saltwater
 
Dosage:  5 mg/kg sd
 
Route:  IV
 
Comments:  Salinity at 33 ppt. Florfenicol amine was not detected in plasma. AUC=407.61 ug*h/mL, MRT=48.92 h. After IV administration, a rapid distribution phase was followed by the slower elimination phase.
 
Cl:  0.012 L/kg/h
 
Vd:  0.62 L/kg
 
Metabolites:  Florfenicol amine
 
Citation:  Aquaculture 307: 71-74
 
Link:  dx.doi.org/10.1016/j.aquaculture.2010.07.003   Opens a new window
 
Genus Species:  Paralichthys olivaceus
 
Drug Class:  Antiobiotic-phenicol
 
t1/2-detail:  38.06+/- 6.10 h
 
Wt gm-detail:  380.4+/- 20.8g
 
Water temp (°C)-detail:  18.5+/- 1.7C
 
Dosage-detail:  5 mg/kg sd
 
Method:  LC/MS
 
Authors-red:  Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI
 
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