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U.S. Department of Health and Human Services

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Title:  Comparison of the depletion of emamectin benzoate (SLICE) residues from skeletal muscle and skin of Atlantic salmon (Salmo salar), for multiple dietary dose regimens at 10C.
 
Authors:  Whyte SK, Westcott JD, Byrne P, Hammell KL
 
Drug:  Emamectin Benzoate
 
Fish species:  Salmon, Atlantic
 
Date:  2011
 
t1/2-hr:  408
 
est:  est
 
Sample:  muscle
 
Ave Weight (gm):  1242
 
Ave Water temp (°C):  10
 
Water:  Saltwater
 
Dosage:  0.05 mg/kg 7d
 
Route:  PO
 
Comments:  Salinity 32-35 ppt. Feeding ration was split between two feed periods. First two days, there was an observed decline in the feeding response to the medicated diet which led to a complete rejection of pellets by the end of the second dosing day. A whole freeze-dried Antartic krill product was top-coated onto the medicated feed to improve palatability of the diet. Fish euthanized with anesthetic overdose (150 mg/L) of MS-222. Emamectin B1a residue level 1d post=61 ng/g, 3d post=55 ng/g, 5d post=37 ng/g, 10d post=32 ng/g, 15d post=25 ng/g, 30d post=13 ng/g, 45d post=7 ng/g. Range 1-45 d post: 146 ng/g - 2 ng/g.
 
Citation:  Aquaculture 315:228-235
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2011.02.043  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antiparasitic-Avermectin
 
t1/2-detail:  17d
 
Wt gm-detail:  1242.0+/-170.3 g (Range: 776.7-1611.2 g)
 
Water temp (°C)-detail:  10.08+/-0.26C
 
Dosage-detail:  50 ug/kg 7d
 
Method:  Not specified
 
Authors-red:  Whyte SK, Westcott JD, Byrne P, Hammell KL
 
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