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Title:
Comparison of the depletion of emamectin benzoate (SLICE) residues from skeletal muscle and skin of Atlantic salmon (Salmo salar), for multiple dietary dose regimens at 10C.
Authors:
Whyte SK, Westcott JD, Byrne P, Hammell KL
Drug:
Emamectin Benzoate
Fish species:
Salmon, Atlantic
Date:
2011
t1/2-hr:
408
est:
est
Sample:
muscle
Ave Weight (gm):
1242
Ave Water temp (°C):
10
Water:
Saltwater
Dosage:
0.05 mg/kg 7d
Route:
PO
Comments:
Salinity 32-35 ppt. Feeding ration was split between two feed periods. First two days, there was an observed decline in the feeding response to the medicated diet which led to a complete rejection of pellets by the end of the second dosing day. A whole freeze-dried Antartic krill product was top-coated onto the medicated feed to improve palatability of the diet. Fish euthanized with anesthetic overdose (150 mg/L) of MS-222. Emamectin B1a residue level 1d post=61 ng/g, 3d post=55 ng/g, 5d post=37 ng/g, 10d post=32 ng/g, 15d post=25 ng/g, 30d post=13 ng/g, 45d post=7 ng/g. Range 1-45 d post: 146 ng/g - 2 ng/g.
Citation:
Aquaculture 315:228-235
Link:
http://dx.doi.org/10.1016/j.aquaculture.2011.02.043
Genus Species:
Salmo salar
Drug Class:
Antiparasitic-Avermectin
t1/2-detail:
17d
Wt gm-detail:
1242.0+/-170.3 g (Range: 776.7-1611.2 g)
Water temp (°C)-detail:
10.08+/-0.26C
Dosage-detail:
50 ug/kg 7d
Method:
Not specified
Authors-red:
Whyte SK, Westcott JD, Byrne P, Hammell KL
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