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U.S. Department of Health and Human Services

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Title:  Distribution and elimination of oxolinic acid in rainbow trout (Oncorhynchus mykiss Walbaum) after single rapid intravascular injection.
 
Authors:  Hustvedt SO, Salte R
 
Drug:  Oxolinic acid
 
Fish species:  Trout, rainbow
 
Date:  1991
 
t1/2-hr:  29
 
Sample:  blood, serum
 
Ave Weight (gm):  1180
 
Ave Water temp (°C):  9
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  Mean serum conc ug/ml 15 min=18.5, 45 min=9.8, 90 min=6.4., 3h=3.3, 6h=3.4, 9h=2.7, 12h=2.4, 24h=1.4, 48h=0.7, 96h=0.34, 144h=0.14, 192h=0.05. Cannulated fish. Saltwater 25 ppt. AUC=200 ug*h/ml. T 1/2 alpha=0.2, beta=2.4, gamma=29.1 h.
 
Cl:  0.083 L/kg/h
 
Vd:  2.6 L/kg
 
Citation:  Aquaculture 92:297-303
 
Link:  http://dx.doi.org/10.1016/0044-8486(91)90035-6  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  alpha=0.2, beta=2.4, gamma=29.1 h, range 19.5-42.8 h gamma
 
Wt gm-detail:  1180 +/-110 g
 
Water temp (°C)-detail:  8.5+/-0.5 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC/RP, HPLC
 
Authors-red:  Hustvedt SO, Salte R
 
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