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U.S. Department of Health and Human Services

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Title:  Distribution and elimination of oxolinic acid in rainbow trout (Oncorhynchus mykiss Walbaum) after single rapid intravascular injection.
 
Authors:  Hustvedt SO, Salte R
 
Drug:  Oxolinic acid
 
Fish species:  Trout, rainbow
 
Date:  1991
 
t1/2-hr:  53
 
Sample:  blood, serum
 
Ave Weight (gm):  575
 
Ave Water temp (°C):  9
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  Mean serum conc ug/ml 15 min=15.0, 45 min=9.5, 90 min=5.7, 3h=3.4, 6h=3.0, 9h=2.4, 12h=2.5, 24h=1.8, 48h=1.5, 73h=1.2, 96h=1.0, 144h=0.7, 192h=nd. Cannulated fish. AUC=212 ug*h/ml. T1/2 alpha=0.5, beta=52.6h.
 
Cl:  0.05 L/kg/h
 
Vd:  2.9 L/kg
 
Citation:  Aquaculture 92:297-303
 
Link:  http://dx.doi.org/10.1016/0044-8486(91)90035-6  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  alpha=0.5, beta=52.6h3, range-2.4-74.2 h beta
 
Wt gm-detail:  575+/-122 g
 
Water temp (°C)-detail:  8.5+/-0.5 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC/RP, HPLC
 
Authors-red:  Hustvedt SO, Salte R
 
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