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U.S. Department of Health and Human Services

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Title:  Bioavailability of oxolinic acid in Atlantic salmon (Salmo salar L.) from medicated feed.
 
Authors:  Hustvedt SO, Salte R, Kvendset O, Vassvik V
 
Drug:  Oxolinic acid
 
Fish species:  Salmon, Atlantic
 
Date:  1991
 
t1/2-hr:  96
 
est:  est
 
Sample:  blood, serum
 
Ave Weight (gm):  932
 
Ave Water temp (°C):  8
 
Water:  Saltwater
 
Dosage:  26 mg/kg sd
 
Route:  PO
 
Comments:  Bioavailability=20% . T 1/2 est from table. Mean serum concentrations ug/ml after oral dose - 6h=10.91, 9h=1.55, 12h=1.76, 24h=1.98, 48h- 1.85, 96h=1.04, 144h=0.51, 192h=0.19, 240=nd. Cmax=2.1 mg/ml at 243.3 h. Salinity 25%.
 
Citation:  Aquaculture 97:305-310
 
Link:  http://dx.doi.org/10.1016/0044-8486(91)90322-X  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  <96 h est from table
 
Wt gm-detail:  932+/-230 g
 
Water temp (°C)-detail:  7.5 C
 
Dosage-detail:  26 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Hustvedt SO, Salte R, Kvendset O, Vassvik V
 
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