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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics and bioavailabilities of 14C-ketocarotenoides, astaxanthin and canthaxanthin, in rainbow trout, Oncorhynchus mykiss.
 
Authors:  Choubert G, Cravedi J-P, Laurentile M
 
Drug:  Canthaxanthin
 
Fish species:  Trout, rainbow
 
Date:  2005
 
t1/2-hr:  6
 
Sample:  blood
 
Ave Weight (gm):  1000
 
Ave Water temp (°C):  17
 
Water:  Freshwater
 
Dosage:  0.24 mg/kg sd
 
Route:  IVC
 
Comments:  Canthaxanthin-14C, AUC 42.09 ugeq/ml. Urine contained < 0.5% radioactivity over 48h. Biliary excretion 3.6%. Aorta and urinary catheterized fish.
 
Cl:  17.3
 
Vd:  208
 
Citation:  Aquaculture Research 36:1526-1534
 
Link:  http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2109.2005.01375.x  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Carotenoid
 
t1/2-detail:  6.02 h
 
Wt gm-detail:  1 kg
 
Water temp (°C)-detail:  17 +/- 1C
 
Dosage-detail:  836.2 kBq/Kg, 0.24 mg/kg
 
Method:  Rad
 
Authors-red:  Choubert G, Cravedi J-P, Laurentile M
 
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