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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Hepatopancreatic and muscular distibution of oxytetracycline antibiotics in farmed pacific white shrimp (Penaeus vannamei): a physiological-based pharmacokinetic model approach
Authors:  Faroongsarng D, Chiayvareesajja S, Chandumpai A, Theapparat Y
Drug:  Oxytetracycline
Fish species:  Shrimp, whiteleg
Date:  2009
t1/2-hr:  95
est:  est
Sample:  muscle
Ave Weight (gm):  16
Ave Water temp (°C):  28
Water:  Saltwater
Dosage:  0.05 mg/kg - sd
Route:  PO
Comments:  Salinity = 20 ppt. Muscular distributions were essentially identical for both dosing routes (IS/PO) and the drug did not accumulate in muscle. There was no mortality in the experimental animals. It was deduced that oxytetracycline distributes in shrimp muscle in an essentially identical manner regardless of route(RM [affinity] =0.828 for IS vs 0.904 for PO).
Citation:  Aquaculture Research 41: 143-152
Link:  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2109.2009.02324.x/abstract  Opens a new window
Genus Species:  Litopenaeus vannamei
Drug Class:  Antibiotic- Tetracycline
t1/2-detail:  estimated from graph
Wt gm-detail:  16.0 +/-4.1
Water temp (°C)-detail:  28 +/-2
Dosage-detail:  50.2 ug/g
Method:  HPLC
Authors-red:  Faroongsrng D, Chiayvareesajja S, Chandumpai A, Theapparat Y