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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Hepatopancreatic and muscular distibution of oxytetracycline antibiotics in farmed pacific white shrimp (Penaeus vannamei): a physiological-based pharmacokinetic model approach
 
Authors:  Faroongsarng D, Chiayvareesajja S, Chandumpai A, Theapparat Y
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, whiteleg
 
Date:  2009
 
t1/2-hr:  95
 
est:  est
 
Sample:  muscle
 
Ave Weight (gm):  16
 
Ave Water temp (°C):  28
 
Water:  Saltwater
 
Dosage:  0.05 mg/kg - sd
 
Route:  PO
 
Comments:  Salinity = 20 ppt. Muscular distributions were essentially identical for both dosing routes (IS/PO) and the drug did not accumulate in muscle. There was no mortality in the experimental animals. It was deduced that oxytetracycline distributes in shrimp muscle in an essentially identical manner regardless of route(RM [affinity] =0.828 for IS vs 0.904 for PO).
 
Citation:  Aquaculture Research 41: 143-152
 
Link:  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2109.2009.02324.x/abstract  Opens a new window
 
Genus Species:  Litopenaeus vannamei
 
Drug Class:  Antibiotic- Tetracycline
 
t1/2-detail:  estimated from graph
 
Wt gm-detail:  16.0 +/-4.1
 
Water temp (°C)-detail:  28 +/-2
 
Dosage-detail:  50.2 ug/g
 
Method:  HPLC
 
Authors-red:  Faroongsrng D, Chiayvareesajja S, Chandumpai A, Theapparat Y
 
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