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Title:
A pharmacokinetic analysis of the effect of temperature on the accumulation of di-2-ethylhexyl phthalate (DEHP) in sheepshead minnow.
Authors:
Karara AH, Hayton WL
Drug:
DEHP-(Di-2-Ethylhexyl Phthalate)
Fish species:
Minnow, sheepshead
Date:
1989
t1/2-hr:
329
Sample:
whole body
Ave Weight (gm):
3
Ave Water temp (°C):
10
Water:
Freshwater
Dosage:
60 ng/ml 2-96 h
Route:
BATH
Comments:
Greatest metabolic clearance at 29C. Bioconcentration factor increased with increasing temperature. (14)C-DEHP
Cl:
101+/-0.5 L/kg/h
Vd:
v1= 87 v2= 2310 L/kg
Citation:
Aquatic Toxicology 15:27-36
Link:
http://dx.doi.org/10.1016/0166-445X(89)90003-9
Genus Species:
Cyprinodon variegatus variegatus
Drug Class:
Organic-Phtalate
t1/2-detail:
328.8 h
Wt gm-detail:
1-5 g
Water temp (°C)-detail:
10 C
Dosage-detail:
60 ng/ml for 2-96 h
Method:
GC, Rad
Authors-red:
Karara AH, Hayton WL
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