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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Disposition of benzocaine in channel catfish.
Authors:  Hayton WL, Szoke A, Kemmemoe BH, Vick AM
Drug:  Benzocaine
Fish species:  Catfish, channel
Date:  1996
t1/2-hr:  77
Sample:  intestinal tract-bile
Ave Weight (gm):  859
Ave Water temp (°C):  25
Water:  Freshwater
Dosage:  70 mg/ mg/l 5 min, 35 mg/l 30 min
Route:  BATH
Comments:  At 10 d the rank-order of residue concentrations was bile>>liver>trunk kidney>head kidney>skin=red muscle>plasma>white muscle. Fish weights- 594+/-134 g (residue) or 1123+/-313 g (autoradiography). Benzocaine (14C). Male and female values mostly the same. Residues ug/g following exposure 0h=72, 4h=556, 25h=387, 6d=132, 10d=43.8, 20d=6.6.
Metabolites:  Acetylbenzocaine (ACBZ), acetyl-p-aminobenzoic acid (AC-PABA)
Citation:  Aquatic Toxicology 36:99-113
Dep-time:  >480 h
Link:  http://dx.doi.org/10.1016/S0166-445X(96)00792-8  Opens a new window
Genus Species:  Ictalurus punctatus
Drug Class:  Anesthetic-Benzocaine
t1/2-detail:  76.8 h but <1% of dose by 25 hr.
Wt gm-detail:  594+/-134 g or 1123+/-313 g*
Water temp (°C)-detail:  24-26 C
Dosage-detail:  70 mg/ mg/l for 5 min, 35 mg/l for 30 min
Method:  HPLC-Rad
Authors-red:  Hayton WL, Szoke A, Kemmemoe BH, Vick AM