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U.S. Department of Health and Human Services

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Title:  Dose-response relationships and pharmacokinetics of vitellogenin in rainbow trout after intravascular administration of 17[alpha]-ethynylestradiol.
 
Authors:  Schultz IR, Orner G, Merdink JL, Skillman A
 
Drug:  Vitellogenin
 
Fish species:  Trout, rainbow
 
Date:  2001
 
t1/2-hr:  42
 
Sample:  blood, plasma
 
Ave Weight (gm):  688
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  0.001 mg/kg of EE2*sd
 
Route:  IVC
 
Comments:  Cannulated fish. *Measured endogenous vitellogenin after induced by 17alpha-ethynylestradiol administration. Cmax 0.046 ug/ml. T max=176h, AUC=8.990 ug/ml/h
 
Citation:  Aquatic Toxicology 51:305-318
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11090892&query_hl=4  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Hormone-Estrogen
 
t1/2-detail:  42.1 +/- 5 h
 
Wt gm-detail:  688+/-107 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  0.001 mg/kg of EE2*sd
 
Method:  GC/MS
 
Authors-red:  Schultz IR, Orner G, Merdink JL, Skillman A
 
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