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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Toxic effects of the non-steroidal anti-inflammmatory drug diclofenac Part I: histopathological alterations and bioaccumulation in rainbow trout.
 
Authors:  Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele RD
 
Drug:  Diclofenac
 
Fish species:  Trout, rainbow
 
Date:  2004
 
Sample:  kidney
 
Ave Weight (gm):  167
 
Ave Water temp (°C):  10
 
Water:  Not Specified
 
Dosage:  0.5 mg/L 28d
 
Route:  BATH
 
Comments:  Fish were anesthetized in ethylenglycol monophenylether, then decapitated. Diclofenac concentration after 28d at 500ug/L dose=2500 ng/g (estimated from graph). Concentration in tissue after 28d increased with increasing dose. Bioconcentration factor (BCF) decreased as dose increased. BCF=5.
 
Citation:  Aquatic Toxicology 68:141-150
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2004.03.014  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Anti-inflammatory-Non-steroidal
 
Wt gm-detail:  167.6+/-20.28g
 
Water temp (°C)-detail:  10.3C
 
Dosage-detail:  Target=500ug/L, actual=501.2+/-1.24
 
Method:  GC/MS
 
Authors-red:  Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele RD
 
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