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Title:
The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus.
Authors:
Mimeault C, Woodhouse AJ, Miao X.-S, Metcalfe CD, Moon TW, Trudeau VL
Drug:
Gemfibrozil
Fish species:
Carp, crucian (goldfish)
Date:
2005
Sample:
blood, plasma
Ave Weight (gm):
26
Ave Water temp (°C):
18
Water:
Freshwater
Dosage:
1.5 ug/l 14 d
Route:
BATH
Comments:
Conc in plasma >75,000 ug/L after 14d exposure. Plasma testosertone reduced by 50%. Steroid acute regulatory protein transcript in testis reduced by 50% after 96 h exposure, but not after 14 d exposure. (Seasonal differences may account for this - Feb vs Nov). BCF=113.
Citation:
Aquatic Toxicology 73:44-54
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15892991&query_hl=10
Genus Species:
Carassius auratus auratus
Drug Class:
Lipid Regulator
Wt gm-detail:
26.4+/-0.7g
Water temp (°C)-detail:
18+/-1°C
Dosage-detail:
1.5 ug/l 14 d
Method:
LC/MS, MS
Authors-red:
Mimeault C, Woodhouse AJ, Miao X.-S, Metcalfe CD, Moon TW, Trudeau VL
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